I fish here in Lake Michigan, I run 4 downriggers mounted towards the rear of the boat, I setup my inside downrigger so the cable enters the water just outside of the boat wake, have found this to improve my number of strikes (or maybe it just seems that way). Here in Michigan I am allowed to run two lures off each rod so my main line of course runs to my cannon ball, then once the downrigger is to depth a "slider" is place on the line from the rod, this will travel to a depth roughly half the distance of the cannon ball. The slider tends to pick up alot of steelhead. I run this basic setup on all 4 downriggers, if I do not put a stacker on my long arms, I run dipsy divers on two rods, one off each side with the weights turned out. If I set my downriggers at 45-65 feet and the dipsy at 160-180 back any fish from 65 feet up to about 22 feet should see a bait, (well thats my logic) works good for locating fish, once found mark with the gps and keep going in cirlces till the bite stops. If the bite is slow, I do not troll with out a strike for more than a half hour then I start changing baits and depths till something is a go.